Outcomes Of Patients Undergoing Radical Cystoprostatectomy For Bladder Cancer With Prostatic Involvement On Final Pathology
May 12, 2017
UroToday - Urothelial carcinoma (UC) can invade the prostate in men with bladder cancer. In fact, it is found in 15%-48% of cystoprostatectomy specimens from patients with bladder cancer.
Prostatic involvement of UC can occur via different routes (by growing transmurally through the bladder wall, or by pagetoid spread along the mucosal surface of the prostatic urethra) and can invade to various depths (superficial, ductal or stromal). We hypothesized that the different sites of origin and depths of invasion may confer different prognosis.
Our study was a retrospective review of 463 consecutive male patients treated with radical cystoprostatectomy for UC of the bladder. We found that 162 (35%) of patients had UC of the prostate, of which 124 (76%) arose in the prostatic urethra and 38 (24%) arose in the bladder and grew through the bladder wall into the prostate. By depth of invasion, 74 (60%) were superficial, 29 (23%) were ductal and 21 (17%) were stromal.
Patients with stromal depth invasion fared far worse that patients with more superficial UC of the prostate (p